Referenced in: none

Automatically associated channels: Kir6.2

Title: Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome.

Authors: C Ikonomidou, P Bittigau, M J Ishimaru, D F Wozniak, C Koch, K Genz, M T Price, V Stefovska, F Hörster, T Tenkova, K Dikranian, J W Olney

Journal, date & volume: Science, 2000 Feb 11 , 287, 1056-60

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/10669420

Abstract
The deleterious effects of ethanol on the developing human brain are poorly understood. Here it is reported that ethanol, acting by a dual mechanism [blockade of N-methyl-D-aspartate (NMDA) glutamate receptors and excessive activation of GABA(A) receptors], triggers widespread apoptotic neurodegeneration in the developing rat forebrain. Vulnerability coincides with the period of synaptogenesis, which in humans extends from the sixth month of gestation to several years after birth. During this period, transient ethanol exposure can delete millions of neurons from the developing brain. This can explain the reduced brain mass and neurobehavioral disturbances associated with human fetal alcohol syndrome.