Referenced in: none

Automatically associated channels: Kir2.3

Title: Synthesis and resolution of racemic eliprodil and evaluation of the enantiomers of eliprodil as NMDA receptor antagonists.

Authors: J Pabel, G Höfner, K T Wanner

Journal, date & volume: Bioorg. Med. Chem. Lett., 2000 Jun 19 , 10, 1377-80

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/10890168

Abstract
A short synthesis of the NMDA receptor antagonist (rac)-Eliprodil (9) and its resolution into the enantiomers by chiral HPLC is described. The enantiomers (R)-9 and (S)-9 were found to exhibit markedly different affinities for NR2B subunit containing NMDA receptors.