Referenced in: none

Automatically associated channels: Kv10.1

Title: Do NMDA receptor kinetics regulate the end of critical periods of plasticity?

Authors: A E Medina, D S Liao, A F Mower, A S Ramoa

Journal, date & volume: Neuron, 2001 Nov 20 , 32, 553-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/11719195

Abstract
Increasing NR2A subunit expression and the associated shortening of the NMDA-EPSC are thought to underlie the loss of diverse types of sensory cortical plasticity. Lu and colleagues (Lu et al., 2001 [this issue of Neuron]) now report that mice lacking the NR2A subunit display normal duration of critical periods of barrel cortex plasticity. Shortening of the NMDA-EPSC is therefore not responsible for the end of these critical periods.