Referenced in: none

Automatically associated channels: Kv10.1

Title: Bioactive fluorinated derivative of amphotericin B.

Authors: Nobuaki Matsumori, Yuichi Umegawa, Tohru Oishi, Michio Murata

Journal, date & volume: Bioorg. Med. Chem. Lett., 2005 Aug 1 , 15, 3565-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/15963721

Abstract
The first stably fluorinated derivative of amphotericin B2 with a fluorine atom in the macrolide skeleton was synthesized using an electrophilic fluorination reagent, Selectfluor. The derivative 2 showed hemolytic, K+ permeable, and antifungal activities similar to those of AmB and thus was expected to be a powerful tool for NMR-based investigations on the mechanism of ion-channel formation by amphotericin B.