Referenced in: none

Automatically associated channels: Kv11.1

Title: Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability.

Authors: Daniela Alberati, Dominik Hainzl, Synèse Jolidon, Eva A Krafft, Anke Kurt, Axel Maier, Emmanuel Pinard, Andrew W Thomas, Daniel Zimmerli

Journal, date & volume: Bioorg. Med. Chem. Lett., 2006 Aug 15 , 16, 4311-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/16757170

Abstract
A novel class of 4-aryl-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1- ones have been discovered and developed as potent and selective GlyT1 inhibitors. The molecules are devoid of activity at the GlyT2 isoform and display excellent selectivities against the mu-opioid receptor as well as the Nociceptin/Orphanin FQ peptide (NOP) receptor. In particular these novel compounds 4 as well as the 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one 3 show improved metabolic stability and pharmacokinetic profiles in rodents compared to previous triazaspiropiperidine series 1 and 2. We have also identified within these diazaspiropiperidine series a key relationship between reducing basicity of the piperidine nitrogen and reducing hERG affinity.