Referenced in: none

Automatically associated channels: Kir2.3

Title: Is a third proton-conducting pathway operative in bacterial cytochrome c oxidase?

Authors: J Salje, B Ludwig, O-M H Richter

Journal, date & volume: Biochem. Soc. Trans., 2005 Aug , 33, 829-31

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/16042608

Abstract
Despite the existence of several three-dimensional structures of cytochrome c oxidases, a detailed understanding of pathways involved in proton movements through the complex remains largely elusive. Next to the two well-established pathways (termed D and K), an additional proton-conducting network ('H-channel') has been proposed for the beef heart enzyme. Yet, our recent mutational studies on corresponding residues of the Paracoccus denitrificans cytochrome c oxidase provide no clues that such a pathway operates in the prokaryotic enzyme.