Referenced in: none

Automatically associated channels: Kv10.1

Title: Retinal neurotoxicity of nitric oxide donors with different half-life of nitric oxide release: involvement of N-methyl-D-aspartate receptor.

Authors: Kazue Takahata, Hiroshi Katsuki, Toshiaki Kume, Ken Ito, Yoshinaga Tochikawa, Shizuko Muraoka, Fumio Yoneda, Satoshi Kashii, Yoshihito Honda, Akinori Akaike

Journal, date & volume: J. Pharmacol. Sci., 2003 Aug , 92, 428-32

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/12939529

Abstract
We compared the degree of neurotoxic outcome in the retina exposed to three nitric oxide (NO) donors with different half-life of NO release. Intravitreal injection of NO donors resulted in a significant decrease in cell density in the ganglion cell layer and thinning of the inner plexiform layer in a half-life time-dependent manner. Concurrent injection of an NO-trapping reagent with an NO donor abolished NO donor-induced retinal damage. (+)-MK-801 also prevented NO-induced retinal damage, indicating that N-methyl-D-aspartate receptors are partly involved in NO-induced neurodegeneration. These results may be relevant to a pathogenic role of NO - glutamate receptor in several ophthalmic disorders.