Referenced in: none

Automatically associated channels: Kv10.1

Title: Regulation of magnesium-inhibited cation current by actin cytoskeleton rearrangement.

Authors: Soon Youn Jeong, Sun Young Shin, Han-Seop Kim, Chang-Dae Bae, Dae-Yong Uhm, Myung-Kyu Park, Sungkwon Chung

Journal, date & volume: Biochem. Biophys. Res. Commun., 2006 Jan 20 , 339, 810-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/16325775

Abstract
Magnesium-inhibited, non-selective cation current (I(MIC)) is activated by depletion of intracellular Mg(2+) and ATP. I(MIC) transports various divalent cations including Mg(2+) and Ca(2+), and is involved in cell viability. We investigated the effect of actin dynamics on I(MIC). Formation of a stable cortical actin network by calyculin A inhibited the activation of I(MIC), while the actin depolymerizing reagent, cytochalasin D, reversed the inhibition. Induction of a dense cortical actin layer by transfecting the constitutively active form of RhoA also inhibited the activation of I(MIC). These results suggest that the activation of I(MIC) may be dynamically regulated by actin cytoskeleton rearrangement.