Referenced in: none

Automatically associated channels: ClC4

Title: Neuronal characteristics of small-cell lung cancer.

Authors: P U Onganer, M J Seckl, M B A Djamgoz

Journal, date & volume: Br. J. Cancer, 2005 Nov 28 , 93, 1197-201

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/16265346

Abstract
Wide ranging experimental evidence suggests that human small-cell lung cancer (SCLC) has a number of molecular and subcellular characteristics normally associated with neurones. This review outlines and discusses these characteristics in the light of recent developments in the field. Emphasis is placed upon neuronal cell adhesion molecules, neurone-restrictive silencer factor, neurotransmitters/peptides and voltage-gated ion, especially Na(+) channels. The hypothesis is put forward that acquisition of such characteristics and the membrane 'excitability' that would follow can accelerate metastatic progression. The clinical potential of the neuronal characteristics of SCLC, in particular ion channel expression/activity, is discussed in relation to possible novel diagnostic and therapeutic modalities.