Referenced in: none

Automatically associated channels: Kv11.1

Title: Molecular ablation of ventricular tachycardia after myocardial infarction.

Authors: Tetsuo Sasano, Amy D McDonald, Kan Kikuchi, J Kevin Donahue

Journal, date & volume: Nat. Med., 2006 Nov , 12, 1256-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17072309

Abstract
Ventricular tachycardia is a common and lethal complication after myocardial infarction. Here we show that focal transfer of a gene encoding a dominant-negative version of the KCNH2 potassium channel (KCNH2-G628S) to the infarct scar border eliminated all ventricular arrhythmias in a porcine model. No proarrhythmia or other negative effects were discernable. Our results demonstrate the potential viability of gene therapy for ablation of ventricular arrhythmias.