Referenced in: none

Automatically associated channels: Kir2.3 , Kv11.1

Title: Constrained 7-fluorocarboxychromone-4-aminopiperidine based Melanin-concentrating hormone receptor 1 antagonists: the effects of chirality on substituted indan-1-ylamines.

Authors: Andrew J Souers, Rajesh R Iyengar, Andrew S Judd, David W A Beno, Ju Gao, Gang Zhao, Michael E Brune, James J Napier, Mathew M Mulhern, John K Lynch, Jennifer C Freeman, Dariusz Wodka, Chong J Chen, H Doug Falls, Sevan Brodjian, Brian D Dayton, Gilbert J Diaz, Eugene N Bush, Robin Shapiro, Brian A Droz, Victoria Knourek-Segel, Lisa E Hernandez, Kennan C Marsh, Regina M Reilly, Hing L Sham, Christine A Collins, Philip R Kym

Journal, date & volume: Bioorg. Med. Chem. Lett., 2007 Feb 15 , 17, 884-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17188866

Abstract
The incorporation of constrained tertiary amines into an existing class of N-benzyl-4-aminopiperidinyl chromone-based MCHr1 antagonists led to the identification of a series of chiral racemic compounds that displayed good to excellent functional potency, binding affinity, and selectivity over the hERG channel. Further separation of two distinct chiral racemic compounds into their corresponding pairs of enantiomers revealed a considerable selectivity for MCHr1 for one configuration, in addition to a striking difference in oral exposure between one pair of enantiomers in diet-induced obese mice. Oral administration of the most potent compound in this class in the same animal model led to significant reduction of fat mass in a semi-chronic model for weight loss.