Referenced in: none

Automatically associated channels: Kv10.1

Title: Why doesn't nicotinic ACh receptor immunoreactivity knock out?

Authors: Ian W Jones, Susan Wonnacott

Journal, date & volume: Trends Neurosci., 2005 Jul , 28, 343-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/15979499

Abstract
Immunochemical analyses of protein expression and localization rely on the specificity of primary immunoreagents. A recent report, using transgenic mice, casts doubt on the specificity of three antibodies commonly used to immunolocalize alpha7 nicotinic ACh receptors. These data highlight the conundrum facing histologists--how 'real' is the labelling they see?