Referenced in: none

Automatically associated channels: Kv10.1

Title: DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activity.

Authors: Damian B van Rossum, Randen L Patterson, King-Ho Cheung, Roxanne K Barrow, Viktoriya Syrovatkina, Gregory S Gessell, Scott G Burkholder, D Neil Watkins, J Kevin Foskett, Solomon H Snyder

Journal, date & volume: J. Biol. Chem., 2006 Dec 1 , 281, 37111-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/16990268

Abstract
We report the cloning and characterization of DANGER, a novel protein which physiologically binds to inositol 1,4,5-trisphosphate receptors (IP(3)R). DANGER is a membrane-associated protein predicted to contain a partial MAB-21 domain. It is expressed in a wide variety of neuronal cell lineages where it localizes to membranes in the cell periphery together with IP(3)R. DANGER interacts with IP(3)R in vitro and co-immunoprecipitates with IP(3)R from cellular preparations. DANGER robustly enhances Ca(2+)-mediated inhibition of IP(3) RCa(2+) release without affecting IP(3) binding in microsomal assays and inhibits gating in single-channel recordings of IP(3)R. DANGER appears to allosterically modulate the sensitivity of IP(3) RtoCa(2+) inhibition, which likely alters IP(3)R-mediated Ca(2+) dynamics in cells where DANGER and IP(3)R are co-expressed.