Referenced in: none

Automatically associated channels: Kv10.1

Title: A choreography of nicotinic receptors directs the dopamine neuron routine.

Authors: Mark A Ungless, Stephanie J Cragg

Journal, date & volume: Neuron, 2006 Jun 15 , 50, 815-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/16772163

Abstract
Modulation of the mesocorticolimbic dopamine system by nicotinic acetylcholine receptors (nAChRs) is thought to play an important role in both health and addiction. However, a clear understanding of how these receptors regulate in vivo firing activity has been elusive. In this issue of Neuron, Mameli-Engvall and colleagues report an impressive and thought-provoking series of in vivo experiments combining single-unit recordings from dopamine neurons with nAChR subunit deletions and region-specific lentiviral subunit re-expression.