PubMed 17095219

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.5

Title: Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias.

Authors: Chris M Jackson, Benjamin Blass, Keith Coburn, Laurent Djandjighian, Gina Fadayel, Andrew J Fluxe, Steven J Hodson, John M Janusz, Michael Murawsky, James M Ridgeway, Ronald E White, Shengde Wu

Journal, date & volume: Bioorg. Med. Chem. Lett., 2007 Jan 1 , 17, 282-4

PubMed link:

Blockade of the Kv1.5 ion channel is a potentially atrial-selective avenue for the treatment of atrial fibrillation and atrial flutter. The development and biological evaluation of a series of thiazolidine-based blockers of Kv1.5 is described.