Referenced in: none

Automatically associated channels: Kir2.3

Title: Verticilide: elucidation of absolute configuration and total synthesis.

Authors: Souichi Monma, Toshiaki Sunazuka, Kenichiro Nagai, Takahiro Arai, Kazuro Shiomi, Ryosuke Matsui, Satoshi Omura

Journal, date & volume: Org. Lett., 2006 Nov 23 , 8, 5601-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17107082

Abstract
Verticilide (1) is a 24-membered cyclic depsipeptide isolated from the culture broth of Verticillium sp. FKI-1033. It inhibits ryanodine binding to ryanodine receptor (RyR) and has insecticidal activity. The stereochemistry of 2-hydroxyheptanoic acid in verticilide was elucidated by chiral HPLC analysis of the degradation product 6 and synthetic (+) and (-)-6. We also describe the practical total synthesis of verticilide. [reaction: see text].