Referenced in: none

Automatically associated channels: Kv10.1

Title: Eag1: an emerging oncological target.

Authors: Luis A Pardo, Walter Stühmer

Journal, date & volume: Cancer Res., 2008 Mar 15 , 68, 1611-3

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/18339837

Abstract
Emerging evidence indicates that ion channels act in a variety of physiologic and pathologic processes beyond electronic signal transmission, including in cancer. We recently found that the potassium channel Eag1 can mediate cancer progression and that a monoclonal antibody, which inhibits Eag1 action, can effectively restrict cancer cell proliferation. We discuss how Eag1 targeting may be useful in diagnostic or therapeutic settings.