Referenced in: none

Automatically associated channels: Kir2.3

Title: [Native and chiral modified NMDA-receptor NR1-binding core ligands modeling].

Authors: A C Korotina, A V Dmitriev, V A Tverdislov

Journal, date & volume: Biomed Khim, 2008 Jul-Aug , 54, 477-81

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/18988464

Abstract
Native and chiral modified (with non-enzymatic Asn racemization) NR1-binding core of NMDA-receptor was modelled by means of molecular dynamic ligand modelling. It was concluded that Gly, D-Ser, D-Asn and D-Thr are ligands of NR1-binding core native NMDA-receptor, whereas the chiral modified NR1-binding core is characterized by the aliphatic non-polar amino acids D-Ala, D-Leu, D-Ile and D-Pro as ligands. The latter amino acids can be considered as effective ligands of NMDA-receptor NR1-binding core in age-related pathology.