Referenced in: none

Automatically associated channels: Slo1

Title: Opsoclonus-myoclonus syndrome in anti-N-methyl-D-aspartate receptor encephalitis.

Authors: Mary Kurian, Patrice H Lalive, Josep O Dalmau, Judit Horvath

Journal, date & volume: Arch. Neurol., 2010 Jan , 67, 118-21

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20065141

Abstract
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis has been recently reported as autoimmune/paraneoplastic encephalitis, affecting mostly young females.To describe opsoclonus-myoclonus syndrome in association with anti-NMDAR antibodies.Case report.Geneva University Hospital. Patient A 23-year-old woman with opsoclonus-myoclonus syndrome.Two weeks after an episode of gastroenteritis, the patient developed symptoms of depression associated with psychomotor slowing, progressive gait instability, and opsoclonus-myoclonus. Cerebrospinal fluid examination showed mild lymphocytic pleocytosis and intrathecal IgG synthesis with oligoclonal bands. The patient's condition worsened rapidly to an akinetic mutism, followed by a period of agitation, delirium, and hallucinations. These gradually subsided; however, a frontal behavior and executive dysfunction persisted 5 months after symptom presentation. No tumor was found. Anti-NMDAR antibodies were found in the cerebrospinal fluid.Opsoclonus-myoclonus may occur in patients with anti-NMDAR encephalitis. Prompt diagnosis of this disorder is important because after tumor removal and immunomodulatory therapies it has a relatively good prognosis.