Referenced in: none

Automatically associated channels: Slo1

Title: Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain.

Authors: Eugene V Grishin, Ganna A Savchenko, Alexander A Vassilevski, Yuliya V Korolkova, Yaroslav A Boychuk, Viacheslav Y Viatchenko-Karpinski, Kirill D Nadezhdin, Alexander S Arseniev, Kirill A Pluzhnikov, Vyacheslav B Kulyk, Nana V Voitenko, Oleg O Krishtal

Journal, date & volume: Ann. Neurol., 2010 May , 67, 680-3

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20437566

Abstract
P2X3 purinoreceptors expressed in mammalian sensory neurons play a key role in several processes, including pain perception. From the venom of the Central Asian spider Geolycosa sp., we have isolated a novel peptide, named purotoxin-1 (PT1), which is to our knowledge the first natural molecule exerting powerful and selective inhibitory action on P2X3 receptors. PT1 dramatically slows down the removal of desensitization of these receptors. The peptide demonstrates potent antinociceptive properties in animal models of inflammatory pain.