Referenced in: none

Automatically associated channels: Kv11.1

Title: Gene therapy approaches to ventricular tachyarrhythmias.

Authors: J Kevin Donahue, Tetsuo Sasano, Kamilla Kelemen

Journal, date & volume: , 2007 Nov-Dec , 40, S187-91

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17993320

Abstract
Ventricular tachycardia arising from a healed myocardial infarction scar continues to be a significant cause of morbidity and mortality. Drug therapy has been inadequate to meet this challenge, and implantable devices are limited by expense and technical problems. We have proposed the use of gene therapy for cardiac arrhythmias. In this review, we present a model of postinfarct ventricular tachycardia, a method for gene delivery to this area, and results of KCNH2-G628S gene transfer to manipulate cellular refractory properties in the arrhythmia model.