Referenced in: none

Automatically associated channels: Slo1

Title: Impact of new technologies for cellular screening along the drug value chain.

Authors: Clemens Möller, Mark Slack

Journal, date & volume: Drug Discov. Today, 2010 May , 15, 384-90

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20206290

Abstract
High-information screening formats, using more physiologically relevant cellular models and readout approaches, are slowly replacing traditional, target-orientated approaches in drug discovery programs. With improved access to primary cells, as well as label-free, non-intrusive methods of compound interrogation (such as automated electrophysiology), high-thoughput screening facilities have to adapt to more complex assay scenarios. The implementation of novel cellular systems, readout technologies and data management in a drug discovery company are essential to improve the current falling productivity evident in recent years throughout the pharmaceutical industry.