Referenced in: none

Automatically associated channels: Kv11.1

Title: Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.

Authors: Stefania Butini, Giuseppe Campiani, Silvia Franceschini, Francesco Trotta, Vinod Kumar, Egeria Guarino, Giuseppe Borrelli, Isabella Fiorini, Ettore Novellino, Caterina Fattorusso, Marco Persico, Nausicaa Orteca, Karin Sandager-Nielsen, Thomas Amos Jacobsen, Kim Madsen, Jorgen Scheel-Kruger, Sandra Gemma

Journal, date & volume: J. Med. Chem., 2010 Jun 24 , 53, 4803-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20481570

Abstract
As a continuation of our efforts to develop innovative ligands for D(3), 5-HT(1A), and 5-HT(2A) receptors with low propensity to block hERG channels, we propose a series bishetero(homo)arylpiperazines 5a-m as novel and potent multifunctional ligands characterized by low occupancy at D(2) and 5-HT(2C) receptors.