Referenced in: none

Automatically associated channels: Kv11.1

Title: Selective GlyT1 inhibitors: discovery of [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia.

Authors: Emmanuel Pinard, Alexander Alanine, Daniela Alberati, Markus Bender, Edilio Borroni, Patrick Bourdeaux, Virginie Brom, Serge Burner, Holger Fischer, Dominik Hainzl, Remy Halm, Nicole Hauser, Synèse Jolidon, Judith Lengyel, Hans-Peter Marty, Thierry Meyer, Jean-Luc Moreau, Roland Mory, Robert Narquizian, Mathias Nettekoven, Roger D Norcross, Bernd Puellmann, Philipp Schmid, Sebastien Schmitt, Henri Stalder, Roger Wermuth, Joseph G Wettstein, Daniel Zimmerli

Journal, date & volume: J. Med. Chem., 2010 Jun 24 , 53, 4603-14

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20491477

Abstract