Referenced in: none

Automatically associated channels: Kv11.1

Title: Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity.

Authors: Lin Yan, Pei Huo, John S Debenham, Christina B Madsen-Duggan, Julie Lao, Richard Z Chen, Jing Chen Xiao, Chun-Pyn Shen, D Sloan Stribling, Lauren P Shearman, Alison M Strack, Nancy Tsou, Richard G Ball, Junying Wang, Xinchun Tong, Thomas J Bateman, Vijay B G Reddy, Tung M Fong, Jeffrey J Hale

Journal, date & volume: J. Med. Chem., 2010 May 27 , 53, 4028-37

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20423086

Abstract