Referenced in: none

Automatically associated channels: Kv11.1

Title: Not all hERG pore domain mutations have a severe phenotype: G584S has an inactivation gating defect with mild phenotype compared to G572S, which has a dominant negative trafficking defect and a severe phenotype.

Authors: Jing Ting Zhao, Adam P Hill, Anthony Varghese, Antony A Cooper, Heikki Swan, Päivi J Laitinen-Forsblom, Mark I Rees, Jonathan R Skinner, Terence J Campbell, Jamie I Vandenberg

Journal, date & volume: J. Cardiovasc. Electrophysiol., 2009 Aug , 20, 923-30

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19490267

Abstract