Referenced in: none

Automatically associated channels: Kv11.1

Title: Ureas with histamine H3-antagonist receptor activity--a new scaffold discovered by lead-hopping from cinnamic acid amides.

Authors: Jesper F Lau, Claus Bekker Jeppesen, Karin Rimvall, Rolf Hohlweg

Journal, date & volume: Bioorg. Med. Chem. Lett., 2006 Oct 15 , 16, 5303-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/16908150

Abstract
A group of tri and tetrasubstituted urea derivatives have been found to be hH(3)-antagonists. The most potent compounds were found in the class of (piperazine-1-yl)-(piperidine-1-yl)-methanones which in addition showed negligible hERG inhibition.