Referenced in: none

Automatically associated channels: ClC4

Title: Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice.

Authors: E I Rugarli, D A Adler, G Borsani, K Tsuchiya, B Franco, X Hauge, C Disteche, V Chapman, A Ballabio

Journal, date & volume: Nat. Genet., 1995 Aug , 10, 466-71

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/7670496

Abstract
We report the unprecedented finding of a gene with a different map position in two mouse strains. The Clcn4 gene was found to map to the X chromosome in the wild Mediterrean mouse, Mus spretus but to chromosome 7 in the inbred strain of laboratory mouse C57BL/6J. These data indicate that a recent evolutionary rearrangement occurred on the mouse sex chromosomes, very close to the pseudoautosomal region. Our data provide molecular evidence for a major divergence near the pseudoautosomal region, consistent with the hypothesis that hybrid sterility in these species results from abnormal pairing of sex chromosomes during male meiosis.