Referenced in: none

Automatically associated channels: Kv10.1

Title: The enemy at the gates. Ca2+ entry through TRPM7 channels and anoxic neuronal death.

Authors: Pierluigi Nicotera, Daniele Bano

Journal, date & volume: Cell, 2003 Dec 26 , 115, 768-70

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/14697196

Abstract
In brain ischemia, gating of postsynaptic glutamate receptors is thought to initiate Ca2+ overload leading to excitotoxic neuronal death. In this issue, Aarts and colleagues describe a novel mechanism, whereby gating of TRPM7, a Ca2+-permeable nonselective cation channel, mediates Ca2+ overload and demise of anoxic neurons.