Referenced in: none

Automatically associated channels: Kir6.2

Title: The effects of NN414, a SUR1/Kir6.2 selective potassium channel opener in subjects with type 2 diabetes.

Authors: M Zdravkovic, M Kruse, K L Rost, J Møss, A Kecskes

Journal, date & volume: Exp. Clin. Endocrinol. Diabetes, 2007 Jun , 115, 405-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17701889

Abstract
Reducing the workload of the beta cell by inhibiting insulin secretion may provide beneficial effects for patients with type 2 diabetes. The aim of this study was to investigate the effect of NN414, a beta cell selective potassium channel opener in patients with type 2 diabetes. 24 patients were treated for seven days (placebo, 1.5, 4.5, and 10 mg/kg). In accordance with the pharmacological profile a significant and selective inhibition of insulin secretion was observed (1 h post dose). There were no statistically significant effects on overall glycaemic control. Based on OGTT derived parameters a borderline significant improvement in beta-cell function (1st and 2nd phase insulin secretion) was observed from Day 1 to Day 7.