Referenced in: none

Automatically associated channels: Kv10.1

Title: The molecular machinery of resurgent sodium current revealed.

Authors: Bruce P Bean

Journal, date & volume: Neuron, 2005 Jan 20 , 45, 185-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/15664169

Abstract
Some TTX-sensitive sodium channels open transiently during recovery from inactivation, generating a "resurgent" sodium current that flows immediately following action potentials. In this issue of Neuron, Grieco and colleagues present evidence that resurgent sodium current results from a novel form of inactivation in which the cytoplasmic tail of the beta4 subunit acts as a classic open-channel blocker.