Referenced in: none

Automatically associated channels: Kv10.1

Title: Staples, tape measures, and bungee cords: a variety of bifunctional reagents for understanding and controlling ion channels.

Authors: Alexandre Mourot, Richard H Kramer

Journal, date & volume: ACS Chem. Biol., 2007 Jul 20 , 2, 451-3

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17649968

Abstract
Chemical modification of proteins with bifunctional reagents has become a widely used technique for analyzing protein structure and dynamics. A new era is emerging, and scientists can now actually control the function of proteins by tethering molecular switches at a desired position. In a new paper, researchers stretch the technique a bit further by using a reactive derivative of a peptide toxin to probe the subunit composition of a voltage-gated K+ channel.