Referenced in: none

Automatically associated channels: Cav3.2

Title: Making the T-type even tinier: corticotropin-releasing factor-mediated inhibition of low-voltage-activated calcium channel activity.

Authors: Diego L Varela, Tamara Hermosilla, Gerald W Zamponi

Journal, date & volume: Mol. Pharmacol., 2008 Jun , 73, 1589-91

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/18326584

Abstract
T-type calcium channels are important for a variety of physiological processes such as brain and heart function. Proper regulation of these channels by second messengers is fundamental; however, our knowledge of the molecular pathways that regulate T-type calcium channels is limited in comparison with other voltage-dependent calcium channels. In this issue of Molecular Pharmacology, Tao et al. (p. 1596) demonstrate that Cav3.2 is regulated by activation of the corticotropin-releasing factor receptor 1 in a Gbetagamma-dependent manner.