Referenced in: none

Automatically associated channels: ClC3 , ClC4

Title: Anion channels: regulation of ClC-3 by an orphan second messenger.

Authors: Alexi K Alekov, Christoph Fahlke

Journal, date & volume: Curr. Biol., 2008 Nov 25 , 18, R1061-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19036336

Abstract
ClC-3 is a ubiquitously expressed chloride channel isoform whose biological function has been a matter of debate for many years. A recent study reporting its regulation by Ins(3,4,5,6)P(4) assigns novel transport functions and cellular roles to ClC-3 and identifies a regulatory pathway that affects epithelial transport and endosomal pH regulation.