Channelpedia

PubMed 19458126


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kir1.1



Title: A comprehensive guide to the ROMK potassium channel: form and function in health and disease.

Authors: Paul A Welling, Kevin Ho

Journal, date & volume: Am. J. Physiol. Renal Physiol., 2009 Oct , 297, F849-63

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19458126


Abstract
The discovery of the renal outer medullary K+ channel (ROMK, K(ir)1.1), the founding member of the inward-rectifying K+ channel (K(ir)) family, by Ho and Hebert in 1993 revolutionized our understanding of potassium channel biology and renal potassium handling. Because of the central role that ROMK plays in the regulation of salt and potassium homeostasis, considerable efforts have been invested in understanding the underlying molecular mechanisms. Here we provide a comprehensive guide to ROMK, spanning from the physiology in the kidney to the organization and regulation by intracellular factors to the structural basis of its function at the atomic level.