Referenced in: none

Automatically associated channels: Slo1

Title: Calcium signals: STIM dynamics mediate spatially unique oscillations.

Authors: Salvatore Mancarella, Youjun Wang, Donald L Gill

Journal, date & volume: Curr. Biol., 2009 Nov 3 , 19, R950-2

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19889372

Abstract
Receptor-induced Ca(2+) oscillations provide 'digitized' signals that confer precise activation of downstream targets. New studies reveal that STIM proteins - sensors of endoplasmic reticulum Ca(2+) levels - cyclically translocate during oscillations, transiently coupling to activate cell-surface Ca(2+) entry channels, resulting in a spatially unique signal that selectively triggers immediate-early gene expression.