Referenced in: none

Automatically associated channels: Kv10.1

Title: Acquisition of different carbapenem resistance mechanisms by an epidemic clonal lineage of Pseudomonas aeruginosa.

Authors: E Edalucci, R Spinelli, L Dolzani, M Letizia Riccio, V Dubois, E Angelo Tonin, G M Rossolini, C Lagatolla

Journal, date & volume: Clin. Microbiol. Infect., 2008 Jan , 14, 88-90

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17986266

Abstract
Multidrug-resistant isolates of a clonal lineage of Pseudomonas aeruginosa producing the VIM-2 metallo-beta-lactamase (MBL), involved in a large outbreak in an Italian hospital, were compared with MBL-negative strains that had caused outbreaks in two French hospitals. Although the isolates had different carbapenem MICs, the VIM-2-producing isolates from Italy carried identical, or very similar, allelic forms of the oprD gene, harboured a common class 1 integron, belonged to the same multilocus sequence type (ST111), and showed macrorestriction profiles that were related to those of the MBL-negative French strains. These results support the concept of independent acquisition of resistance determinants by members of a widespread clonal lineage of P. aeruginosa.