Referenced in: none

Automatically associated channels: Kv11.1

Title: Reduction of hERG inhibitory activity in the 4-piperidinyl urea series of H3 antagonists.

Authors: Michael Berlin, Yoon Joo Lee, Christopher W Boyce, Yi Wang, Robert Aslanian, Kevin D McCormick, Steve Sorota, Shirley M Williams, Robert E West, Walter Korfmacher

Journal, date & volume: , 2010 Jan 28 , ,

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20188550

Abstract
Structural features of the substituted 4-piperidinyl urea analogs 1, responsible for the H3 antagonist activity, have been identified. Structure-activity relationship of the H3 receptor affinity, hERG ion channel inhibitory activity and their separation is described. Preliminary pharmacokinetic evaluation of the compounds of the series is addressed.