Referenced in: none

Automatically associated channels: Slo1

Title: Vasopressin-independent mechanisms in controlling water homeostasis.

Authors: Carrie Y Y Cheng, Jessica Y S Chu, Billy K C Chow

Journal, date & volume: J. Mol. Endocrinol., 2009 Sep , 43, 81-92

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19318428

Abstract
The maintenance of body water homeostasis depends on the balance between water intake and water excretion. In the kidney, vasopressin (Vp) is a critical regulator of water homeostasis by controlling the insertion of aquaporin 2 (AQP2) onto the apical membrane of the collecting duct principal cells in the short term and regulating the gene expression of AQP2 in the long term. A growing body of evidence from both in vitro and in vivo studies demonstrated that both secretin and oxytocin are involved as Vp-independent mechanisms regulating the renal water reabsorption process, including the translocation and expression of AQP2. This review focuses on how these two hormones are potentially involved as Vp-independent mechanisms in controlling water homeostasis.