Referenced in: none

Automatically associated channels: Kv11.1

Title: Famotidine neither affects action potential parameters nor inhibits human ether-a-go-go-related gene (hERG) K+ current.

Authors: Yuji Nakamura, Akira Takahara, Atsushi Sugiyama

Journal, date & volume: J Toxicol Sci, 2009 Oct , 34, 563-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19797865

Abstract
The direct effects of famotidine, a selective histamine H(2) receptor antagonist, on the cardiac repolarization process were assessed using two in vitro test systems. Neither famotidine (0.1 and 1 microM), nor its solvent, dimethylsulfoxide (0.1%), affected any of the action potential parameters of guinea-pig papillary muscles, whereas the positive control, dl-sotalol (30 microM), significantly prolonged the action potential duration. Moreover, neither famotidine (0.1, 1 and 10 microM) nor dimethylsulfoxide affected the human ether-a-go-go-related gene (hERG) K(+) current expressed in Chinese hamster ovary-K1 cells, whereas the positive control, E-4031 (0.1 microM), significantly decreased the current. These results indicate famotidine does not directly affect the cardiac repolarization process.