Referenced in: none

Automatically associated channels: Slo1

Title: The beta1 subunit of Na+/K+-ATPase interacts with BKCa channels and affects their steady-state expression on the cell surface.

Authors: Smita Jha, Stuart E Dryer

Journal, date & volume: FEBS Lett., 2009 Oct 6 , 583, 3109-14

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19729011

Abstract
Large conductance Ca2+-activated K+ channels (BKCa) encoded by the Slo1 gene play a role in the physiological regulation of many cell types. Here, we show that the beta1 subunit of Na+/K+-ATPase (NKbeta1) interacts with the cytoplasmic COOH-terminal region of Slo1 proteins. Reduced expression of endogenous NKbeta1 markedly inhibits evoked BKCa currents with no apparent effect on their gating. In addition, NKbeta1 down-regulated cells show decreased density of Slo1 subunits on the cell surface.