Referenced in: none

Automatically associated channels: Kv11.1

Title: Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists.

Authors: Kaimei Cho, Makoto Ando, Kensuke Kobayashi, Hiroshi Miyazoe, Toshiaki Tsujino, Sayaka Ito, Tomoki Suzuki, Takeshi Tanaka, Shigeru Tokita, Nagaaki Sato

Journal, date & volume: Bioorg. Med. Chem. Lett., 2009 Aug 15 , 19, 4781-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19596193

Abstract
A novel series of cyclohexanamine derivatives was designed and synthesized as potent and selective human neuropeptide Y Y1 receptor antagonists. Modification of high-throughput screening hit compound 1 resulted in the identification of compound 3i, which displays potent Y1 activity and good selectivity towards hERG K(+) channel and serotonin transporter.