Referenced in: none

Automatically associated channels: Kir1.1 , Kir6.2

Title: Sulfonylurea treatment in a girl with neonatal diabetes (KCNJ11 R201H) and celiac disease: impact of low compliance to the gluten free diet.

Authors: Maurizio Delvecchio, Clara Zecchino, Maria Felicia Faienza, Angelo Acquafredda, Fabrizio Barbetti, Luciano Cavallo

Journal, date & volume: Diabetes Res. Clin. Pract., 2009 Jun , 84, 332-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19345438

Abstract
A girl with celiac disease and KCNJ11 mutation was transferred to glibenclamide when 19.8 years old. When her compliance to the gluten free diet worsened, her metabolic control deteriorated. Since glibenclamide is absorbed in the intestine, its absorption seems to be impaired by chronic malabsorption, increasing the risk of hyperglycaemia.