Referenced in: none

Automatically associated channels: Kv11.1

Title: 1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity.

Authors: Gavin A Whitlock, Julian Blagg, Paul V Fish

Journal, date & volume: Bioorg. Med. Chem. Lett., 2008 Jan 15 , 18, 596-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/18240382

Abstract
A novel series of 1-(2-phenoxyphenyl)methanamines is disclosed, which possess selective dual 5-HT and NA reuptake pharmacology. Analogues with good human in vitro metabolic stability, hERG selectivity and passive membrane permeability were identified.