Referenced in: none

Automatically associated channels: Kv2.1 , Slo1

Title: A Drosophila mutation that eliminates a calcium-dependent potassium current.

Authors: T Elkins, B Ganetzky, C F Wu

Journal, date & volume: Proc. Natl. Acad. Sci. U.S.A., 1986 Nov , 83, 8415-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2430288

Abstract
A mutation of Drosophila, slowpoke (slo), specifically abolishes a Ca2+-dependent K+ current, IC, from dorsal longitudinal flight muscles of adult flies. Other K+ currents remain normal, providing evidence that IC is mediated by a molecularly distinguishable set of channels. The pharmacological properties of IC are similar to those of Ca2+-dependent currents in some vertebrate cells. The muscle action potential was significantly lengthened in slo flies, indicating that IC plays the major role in its repolarization.