Referenced in: none

Automatically associated channels: Kir6.2

Title: Changes in the ratio of two separate toxin binding sites on the sodium channel protein during rat brain development.

Authors: J Baumgold

Journal, date & volume: Brain Res., 1985 Jan , 349, 271-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2580602

Abstract
The development of two separate toxin binding sites from sodium channels of rat brain was studied. Whereas [3H]saxitoxin binding developed gradually, reaching adult levels by 4.5 weeks after birth, the binding of [125I]scorpion toxin increased rapidly for the first 10 days after birth, then declined. The stoichiometric ratio of [3H]saxitoxin binding site to [125I]scorpion toxin binding sites changed during development from 0.5 in 8 day old rats to 1.9 in adult rats, implying separate biological regulation for each of these sites.