Referenced in: none

Automatically associated channels: Kir2.3

Title: Mitogen induction of ion channels in murine T lymphocytes.

Authors: T E DeCoursey, K G Chandy, S Gupta, M D Cahalan

Journal, date & volume: J. Gen. Physiol., 1987 Mar , 89, 405-20

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2435845

Abstract
Using gigohm-seal recording, we studied ion channel expression in resting and activated T lymphocytes from mice. Both the number of channels per cell and the predominant type of K+ channel depend upon the state of activation of the cell. Unstimulated T cells express small numbers of K+ channels, typically a dozen per cell, and are heterogeneous, usually expressing either type n or type l K+ channels (see DeCoursey, T. E., K. G. Chandy, S. Gupta, and M. D. Cahalan. 1987. Journal of General Physiology. 89:379-404). 1 d after stimulation by the murine T cell mitogen concanavalin A, large numbers of type n K+ channels appear in enlarged, activated cells. Type n channels appear in activated cells with a time course consistent with that reported for mitogen-induced enhancement of protein synthesis. Voltage-gated tetrodotoxin-sensitive Na+ channels present in about one-third of unstimulated cells from the MRL-n strain are increased approximately 10-fold after activation.