Referenced in: none

Automatically associated channels: Kir6.2

Title: Age-related reduced affinity in [3H]nitrendipine labeling of brain voltage-dependent calcium channels.

Authors: S Govoni, R A Rius, F Battaini, A Bianchi, M Trabucchi

Journal, date & volume: Brain Res., 1985 May 6 , 333, 374-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2581663

Abstract
Literature data indicate a reduced calcium uptake in synaptosomes prepared from old rat brains. On this line, the present paper investigates the binding of ([3H]NDP) to brain synaptic membranes prepared from rats at different ages from birth up to 24 months of age. The binding is undetectable at birth but reaches within 9-18 day the values observed in adults [3H]NDP binding affinity and sensitivity to calcium were decreased in old rats (24 months). Tritiated dihydropyridines are believed to label voltage-dependent calcium channels (VDC). The observed age-related reduction in binding suggests that the characteristics of VDC in the aged brain may change.