Referenced in: none

Automatically associated channels: Kv10.1 , Slo1

Title: [Action of chloramine-T on the processes of sodium channel activation and inactivation in neuroblastoma cells]

Authors: E D Nosyreva, I I Grishchenko, Iu A Neguliaev

Journal, date & volume: , 1987 , 19, 789-95

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2452354

Abstract
Effect of chloramine-T, the specific reagent on methionine residues, on gating of sodium channels was studied in neuroblastoma cell membrane. After the chloramine treatment the inactivation became slower, incomplete and the steepness of its voltage dependence considerably decreased; the inactivation curve was shifted towards depolarization. Time course of activation did not change. The activation curve shifted towards negative potentials, its slope being insignificantly decreased. Effective charge of activation as determined from the limiting logarithmic slope of the activation decreased by a factor of 1.17. Possible explanations of the phenomena observed are discussed.