Referenced in: none

Automatically associated channels: Kir2.3

Title: Kinetics of sodium activation in giant axons of squid (Doryteuthis bleekeri).

Authors: G Matsumoto, M Ichikawa

Journal, date & volume: Neuroscience, 1985 Jan , 14, 327-34

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2579353

Abstract
The variation with time of the rising phase of the sodium conductance in squid giant axons was fitted to the Xth power of running integrals of the colchicine-sensitive components of the asymmetry currents, where the running integrals were experimentally obtained. We found that excellent fitting was obtained for all of the potentials examined from -60 to +60 mV, when we put the value of X equal to 3 at potentials above 10 mV and equal to 5 below -20 mV, and it varied continuously from 3 to 5 when pulse potentials changed from 10 to -25 mV. Further, it was found that the voltage dependence of the peak sodium currents was fitted to the third power of charges carried by the colchicine-sensitive component of the asymmetry current by the moment when the sodium current attained its peak. These results agree well with the expectation by Hodgkin and Huxley [(1952) J. Physiol., Lond. 117, 500-544] although the gating kinetics differ from the Hodgkin-Huxley prediction [Matsumoto, Ichikawa and Tasaki (1983) J. Membr. Biol. 77, 93-99].